A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 9/107 (2006.01) A61K 39/00 (2006.01) A61P 25/28 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2739318
A safe and effective vaccine to prevent, slow, halt or reverse progression of Alzheimer's disease in human patients is disclosed. The vaccine includes A.beta.1-42 or an beta amyloid self epitope (e.g. A.beta.1-15, or other 7-mer or 15-mer peptide epitopes derived from A.beta.1-42) conjugated to an immunogenic carrier (e.g. DT) formulated in a water-in-oil Th2- biased adjuvant/delivery system.
L'invention concerne un vaccin sûr et efficace pour prévenir, ralentir, stopper ou inverser l'évolution de la maladie d'Alzheimer chez des patients humains. Le vaccin comprend Aß1-42 ou un auto-épitope de bêta-amyloïde (par exemple, Aß1-15, ou d'autres épitopes peptidiques 7-mères ou 15-mères dérivés de Aß1-42) conjugué à un support immunogène (par exemple DT) formulé dans un adjuvant/système de délivrance à biais Th2 eau-dans-l'huile.
Blackburn Peter
Grimes Stephen
Kirby Eades Gale Baker
Mercia Pharma Llc
LandOfFree
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