Immunotherapeutic methods using epitopes of wt-1 and gata-1

Details Immunotherapeutic methods using epitopes of wt-1 and gata-1 Immunotherapeutic methods using epitopes of wt-1 and gata-1

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/08 (2006.01) C07K 4/12 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2348956

A peptide comprising the amino acid sequence RMFPNAPYL or a portion or variant thereof provided that the peptide is not intact human WT-I polypeptide or a peptide comprising the amino acid sequence CMTWNQMNL or a portion or variant thereof provided that the peptide is not intact human WT-I polypeptide or a peptide comprising the amino acid sequence HLMPFPGPLL or a portion or variant thereof provided that the peptide is not intact human gata-1 polypeptide, and polynucleotides encoding these peptides. The peptides and polynucleotides are useful as cancer vaccines.

L'invention concerne un peptide comprenant la séquence d'acides aminés RMFPNAPYL ou une partie ou une variante de cette dernière mais ledit peptide n'est pas un peptide WT-1 humain intact. L'invention concerne également un peptide comprenant la séquence d'acides aminés CMTWNQMNL ou une partie ou une variante de cette dernière mais ledit peptide n'est pas un polypeptide WT-1 humain intact. L'invention concerne aussi un peptide comprenant la séquence d'acides aminés HLMPFGPLL ou une partie ou une variante de cette dernière mais ledit peptide n'est pas un polypeptide gata-1 humain intact. L'invention traite aussi de polynucléotides codant ces peptides. Les peptides et les polynucléotides présentent une grande utilité comme vaccins contre le cancer.

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