C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/24 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2745736
Improved vaccines which include a nucleotide sequence that encodes IL-12, GM-CSF, IL-1, TNF- .alpha., TNF- .beta., IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and/or BL-1 operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Pharmaceutical compositions comprising nucleic acid molecules that encode one or more immunomodulatory proteins selected from the group consisting of IL-12, GM- CSF, IL-1, TNF- .alpha., TNF- .beta., IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and BL-1 are disclosed. An immunomodulatory protein, BL-1, and nucleic acid molecules that encode BL-1 are disclosed. Methods of making and using BL-1 are disclosed.
Ayyavoo Velpandi
Boyer Jean D.
Kim Jong J.
Wang Bin
Weiner David B.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Trustees Of The University Of Pennsylvania
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