Immunotherapy compositions, method of making and method of...

C - Chemistry – Metallurgy – 12 – N

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C12N 11/14 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 11/02 (2006.01)

Patent

CA 2548992

The present invention directs to compositions and methods for modulating immune system. One aspect of the present invention relates to a composition comprising FADD-dependent signaling pathway modulators. Another aspect of the present invention relates to biodegradable microparticles, such as a chitosan microparticle, or PLGA/PEI microparticle, designed to deliver nucleic acids and/or proteins, such as FADD-dependent signaling pathway modulators, to boost different pathways of an immune response. Another aspect of the present invention relates to the method of making biodegradable microparticles. The further aspect of the present invention relates to the use of the chitosan and other polycationic microparticles to deliver FADD-dependent signaling pathway modulators to modulate immune system for the prevention and/or treatment infectious diseases and cancers.

La présente invention concerne des compositions et des méthodes de modulation du système immunitaire. Un aspect de la présente invention se rapporte à une composition comprenant des modulateurs de la voie de signalisation dépendant du domaine effecteur de mort associé à Fas (FADD). Un autre aspect de la présente invention concerne des microparticules biodégradables, telles qu'une particule de chitosane ou une microparticule PLGA/PEI, conçue pour apporter des acides nucléiques et/ou des protéines, tels que des modulateurs de la voie de signalisation dépendant de FADD, pour amplifier/relancer différentes voies d'une réponse immunitaire. Un autre aspect de la présente invention se rapporte à une méthode de préparation de microparticules biodégradables. Le dernier aspect de cette invention porte sur l'utilisation du chitosane et d'autres microparticules polycationiques pour apporter des modulateurs de la voie de signalisation dépendant de FADD afin de moduler le système immunitaire en vue de prévenir et/ou de traiter des maladies infectieuses et des cancers.

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