Immunotherapy of autoimmune disorders

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2582919

Compositions and methods for treating autoimmune diseases are described. In particular, the use of B cell depleting agents and cytotoxic drug/B cell depleting agent conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) in treating autoimmune diseases is described. Combination therapies and compositions for treating autoimmune diseases, including the B cell depleting agents, conjugates and/or anti-cytokine agents, are also described.

L'invention concerne des compositions et des méthodes destinées au traitement de maladies auto-immunes. L'invention concerne en particulier l'utilisation d'agents de déplétion des lymphocytes B et de conjugués composés d'un agent de déplétion des lymphocytes B et d'un médicament cytotoxique présentant une charge médicamenteuse sensiblement supérieure à celle obtenue dans les procédures passées, ainsi qu'une agrégation réduite et une fraction conjuguée faible (LCF) lors du traitement de maladies auto-immunes. L'invention concerne également des polythérapies et des compositions destinées au traitement de maladies auto-immunes, y compris des agents de déplétion des lymphocytes B, des conjugués et/ou des agents anticytokines.

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