C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2234666
This invention provides for immunotoxins comprising a Pseudomonas exotoxin (PE) that does not require proteolytic activation for cytotoxic activity attached to an Fv antibody fragment having a variable heavy chain region bound through at least one disulfide bond to a vairable light chain region. The combination of a "disulfide-stabilized" binding agent fused to a PE that does not require proteolitic activation provides an immunotoxin having surprising cytotoxic activity.
L'invention porte sur des immunotoxines comprenant une exotoxine Pseudomonas (PE), ne nécessitant pas d'activation protéolytique de leur activité cytotoxique et liées à un fragment d'anticorps Fv présentant une région à chaîne lourde variable reliée au moins par l'intermédiaire d'une liaison bisulfure à une région à chaîne légère variable. La combinaison d'un agent de fixation "stabilisé au bisulfure" fusionné avec une PE ne nécessitant pas d'activation protéolytique donne une immunotoxine présentant une activité cytotoxique surprenante.
Kuan Chien-Tsun
Pastan Ira
Department O. Artment Of Health And Human Services The United States Of America Represented By The Secretary
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
LandOfFree
Immunotoxin containing a disulfide-stabilized antibody fragment does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunotoxin containing a disulfide-stabilized antibody fragment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunotoxin containing a disulfide-stabilized antibody fragment will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1899506