C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/34 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2409746
The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti- T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
La présente invention porte sur de nouvelles immunotoxines de recombinaison basées sur la toxine de la diphtérie, et pus spécifiquement, sur des protéines de fusion d'immunotoxines des anti-lymphocytes T. L'invention porte également sur des immunotoxines qui peuvent être exprimées dans les bactéries, la levure ou des cellules mammaliennes ; sur un moyen d'expression de la protéine de fusion des immunotoxines. L'accent est mis sur le fait que cet abrégé doit être conforme aux règles exigeant que le chercheur ou le lecteur puisse déterminer rapidement l'objet de l'invention. Il est également entendu que cet abrégé ne sera pas utilisé pour interpréter ou limiter le domaine d'application ou le sens des revendications.
Digan Mary Ellen
Hexham Jonathan Mark
Hu Huaizhong
Ma Shenglin
Neville David M. Jr.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Gowling Lafleur Henderson Llp
Novartis Ag
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