Immunovectors for the intracellular and intranuclear transport

Details Immunovectors for the intracellular and intranuclear transport Immunovectors for the intracellular and intranuclear transport

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/18 (2006.01) C12N 5/18 (2006.01)

Patent

CA 2224413

A product for coupling a biologically active principle with an immunovector, characterised in that the immunovector is capable of enabling the biologically active principle to be internalised into eukaryotic cells, and in that said immunovector has an affinity for the cell DNA to such an extent that it can transfer the biologically active principle into or to the immediate vicinity of the cell nuclei.

L'invention concerne un produit de couplage entre un principe biologiquement actif et un immunovecteur caractérisé à la fois par la capacité de l'immunovecteur à permettre l'internalisation dans des cellules eucaryotes du principe biologiquement actif, et par l'affinité de l'immunovecteur pour l'ADN de ces cellules, au point de le rendre apte à transférer le principe biologiquement actif à proximité immédiate des noyaux de ces cellules ou dans ces noyaux.

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