Impermeable capsules

A - Human Necessities – 61 – K

Patent

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Details

A61K 8/11 (2006.01) A61Q 11/00 (2006.01) A61K 8/72 (2006.01)

Patent

CA 2687325

A capsule comprising a core and a shell surrounding and enclosing the core, the shell comprising at least one first polymer having a first water solubility parameter, and at least one second polymer having a water solubility parameter higher than the first water solubility parameter, wherein the second polymer is crosslinked, and/or all of the at least one second polymer is present in an amount that is less than all of the at least one first polymer. Upon exposure to an aqueous medium, the first polymer begins to swell, and water begins to leak into the capsule. Also, the second polymer is attracted to the entering water. As the second polymer absorbs water and swells, the mean free space in the shell decreases and the tortuous pathway for materials crossing the boundary of the wall increases. As a result, leakage rates across the capsule wall decrease.

La présente invention concerne une capsule comportant un noyau et un enrobage entourant et renfermant le noyau, l'enveloppe comprenant au moins un premier polymère ayant un premier paramètre d'hydrosolubilité, au moins un second polymère ayant un paramètre d'hydrosolubilité supérieur au premier paramètre d'hydrosolubilité , le second polymère étant réticulé, et/ou la totalité du second polymère est présente en une quantité inférieure à la totalité du premier polymère. Lors de son exposition à un milieu aqueux, le premier polymère commence à se gonfler, et l'eau commence à pénétrer dans la capsule. En outre, le second polymère est attiré vers l'eau de pénétration. Au fur et à mesure que le second polymère absorbe l'eau et se gonfle, l'espace libre moyen dans l'enveloppe se réduit et le trajet tortueux des substances traversant la limite de la paroi s'accroît. Par conséquent, des taux de fuite à travers la paroi de la capsule diminuent.

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