Implant attachement stabilizer

Details Implant attachement stabilizer Implant attachement stabilizer

A - Human Necessities

61

K

A61K 31/663 (2006.01) A61P 19/00 (2006.01) A61F 2/28 (2006.01) A61L 27/54 (2006.01) C07F 9/38 (2006.01)

Patent

CA 2346014

Insertion stabilizers for implants which contain as the active ingredient methanebisphosphonic acid derivatives represented by general formula (I) or hydrates thereof wherein X, Y, m, n, <u>---</u>, A, B, R1, R2, R3 and R4 are each as defined in the description. The above-described methanebisphosphonic acid derivatives represented by general formula (I) or hydrates thereof have an effect of inhibiting the proliferation of interstitial tissues or an effect of inhibiting the production of osteolytic factors and therefore particularly inhibit the proliferation of interstitial tissues associating the insertion of an implant and inhibit the production of osteolytic factors around the implant to thereby inhibit osteolysis. Owing to these characteristics, these compounds are effective in preventing implants from loosening or fall-off and thus make it possible to prolong the insertion period of implants such as artificial joints and dental implants.

L'invention porte sur des stabilisateurs d'insertion pour implants dont le principe actif consiste en dérivés (ou leurs hydrates) de l'acide méthanebisphosphonique, de formule générale (I) dans laquelle X, Y, m, n, <u>---</u>,A, B, R?1¿, R?2¿, R?3¿, et R?4¿ sont définis dans la description. Lesdits dérivés et hydrates ont pour effet d'inhiber la prolifération des tissus interstitiels liée à l'implantation et celle des facteurs ostéolytiques entourant l'implant, d'où une inhibition de l'ostéolyse. En raison de ces caractéristiques, ces composés empêchent le décollement et la chute des implants et prolongent la période d'insertion des implants du type prothèse articulaire ou implant dentaire.

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