Implant for transport and release for pharmacologically...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/44 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 27/54 (2006.01) A61L 31/06 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2491282

The present invention relates to an implant comprising (a) a polymer of the general formula (I) as a matrix material of the implant, wherein n is from 2 to .infin., and R1 to R6 are the same or different and represent a halogenalkoxy, alkoxy, alkylsulfonyl, dialkylamino or aryloxy group or a heterocycloalkyl or heteroaryl group having nitrogen as a heteroatom, and at least one halogen substituent; and (b) at least one pharmacologically active agent incorporated into the matrix material, a process for producing the same and the use of a mixture of a polymer having the formula (I) and a pharmacologically active agent for the preparation of a pharmaceutical composition in the form of an implant for the treatment of disorders caused by implantation of said implant in a patient.

L'invention concerne un implant comprenant: a) un polymère représenté par la formule (I) utilisé comme matériau matriciel dudit implant, où n est compris entre 2 et 8, et R?1¿ à R?6¿ sont identiques ou différents et représentent un groupe halogenalcoxy, alcoxy, alkylsulfonyle, dialkylamino ou aryloxy ou un groupe hétérocycloalkyle ou hétéroaryle comprenant un azote comme hétéroatome, et au moins un substituant halogène; et b) au moins un agent pharmacologiquement actif incorporé dans le matériau matriciel. L'invention concerne également un procédé permettant de produire un implant et l'utilisation d'un mélange de polymère représenté par la formule (I) et d'un agent pharmacologiquement actif permettant de préparer une composition pharmaceutique sous forme d'implant afin de traiter des troubles provoqués par l'implantation dudit implant chez un patient.

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