Implant improving local bone formation

Details Implant improving local bone formation Implant improving local bone formation

A - Human Necessities

61

L

A61L 27/56 (2006.01) A61F 2/28 (2006.01) A61L 27/04 (2006.01) A61L 27/14 (2006.01) A61L 27/32 (2006.01)

Patent

CA 2508085

A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.

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