Implantable acrylamide copolymer hydrogel for therapeutic uses

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61L 27/26 (2006.01) A61L 27/38 (2006.01) A61L 27/52 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01) A61L 31/14 (2006.01)

Patent

CA 2240721

The hydrogel is a copolymer of an N-substituted methacrylamide or acrylamide, a cross-linking agent and a complex sugar or derivative, a tissue adhesion peptide or a polymer conjugate with antibodies, the polymer being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%. It can be used for tissue regeneration and for organ repair, for example, in the developing and adult nervous system.

Cet hydrogel est un copolymère constitué par un acrylamide ou méthacrylamide N-substitué, par un agent de réticulation et par un sucre ou dérivé de sucre complexe, un peptide d'adhésion tissulaire ou un conjugué polymère avec des anticorps, le polymère étant hétérogène, élastiquement déformable et présentant une teneur en eau d'équilibre d'au moins 80 % environ. Cet hydrogel peut être utilisé pour la régénération des tissus et pour la reconstitution d'organes, notamment dans le système nerveux en pleine croissance et au stade adulte.

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