Implantable active ingredient depot

Details Implantable active ingredient depot Implantable active ingredient depot

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 9/127 (2006.01) A61K 31/337 (2006.01) A61K 31/555 (2006.01) A61K 47/24 (2006.01) A61K 47/34 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2378401

This invention relates to an implantable active ingredient depot for therapeutically active substances. The fields of application are in medicine and the pharmaceutical industry. The aim of the invention is the application of gel-like cubic mesophases of the monooleine-water system as an implantable active ingredient depot for the treatment of tumors during oncological therapy and in gene therapy. A rational membrane design has been developed to control the release of the active ingredient over time and to control the amount released. The implantable active ingredient according to the invention consists of a lipid matrix which is capable of forming cubic phases in which modifier-molecules have been integrated and contains pharmaceutically active substances. Monooleine is the preferred lipid matrix.

L'invention concerne un dépôt de principe actif implantable destiné à des substances d'action thérapeutique. Cette invention trouve des applications en médecine et dans l'industrie pharmaceutique. L'invention vise à utiliser des mésophases cubiques ayant la consistance d'un gel du système monooléine-eau comme dépôt de principe actif implantable pour traiter des tumeurs dans le cadre de la thérapie du cancer et de la thérapie génique. Pour pouvoir commander la libération des principes actifs en termes de temps et de quantité, il faut développer une membrane de conception rationnelle. Le dépôt de principe actif implantable selon l'invention est composé - d'une matrice lipide apte à former des phases cubiques, - de molécules de modificateur insérées dans la matrice et de substances pharmaceutiquement actives contenues dans la matrice. Une matrice lipide préférée est une monooléine.

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