Implantable agarose-collagen beads containing cells which...

Details Implantable agarose-collagen beads containing cells which... Implantable agarose-collagen beads containing cells which...

C - Chemistry, Metallurgy

12

N

C12N 11/04 (2006.01) A61K 9/66 (2006.01) A61K 35/23 (2006.01) A61P 35/00 (2006.01) A61L 27/38 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2250880

Implantable beads which are made of agarose and collagen, and/or coated with agarose have incorporated within samples of cells. The cells produce diffusible biological products. The beads may be used as implants to modulate a recipient's immune response. The beads may also be used in an in vitro context to encourage specific types of cells to grow, to produce desirable products in culture, or to suppress growth of certain cells. The implants may also suppress growth of certain cells following administration to a subject.

L'invention se rapporte à des billes implantables, constituées d'agarose et de collagène et/ou recouvertes d'agarose, qui ont été incorporées à des échantillons de cellules. Les cellules produisent des produits biologiques diffusibles. Les billes peuvent être utilisées sous forme d'implants servant à moduler une réponse immunitaire d'un receveur. Lesdites billes peuvent également être utilisées in vitro pour encourager la croissance de certains types de cellules, pour produire des produits souhaités en culture ou pour supprimer la croissance de certaines cellules. Une fois administrés à un sujet, lesdits implants peuvent également supprimer la croissance de certaines cellules.

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