Implantable and refillable biohybrid artificial pancreas

Details Implantable and refillable biohybrid artificial pancreas Implantable and refillable biohybrid artificial pancreas

A - Human Necessities

61

M

A61M 37/00 (2006.01) A61F 2/02 (2006.01)

Patent

CA 2147261

An artificial pancreas system which mini- mizes the volume of the artificial pancreas by not encapsulating each islet (15) is taught wherein the islets (15) are separated and held within a polymer- ic matrix (14) which is soluble in an aqueous solu- tion below body temperature but insoluble in aque- ous solution at or above body temperature. The po- lymer-islet mixture is contained in a biocompatible membrane pouch (10) having access means such as entry and exit ports (31, 32). The solubility makes it possible to replace the contents of the pouch (10) by solubilizing the matrix (14) simply by lowering the temperature below the LCST. The pouch (10) is permeable to insulin and other substances of simi- lar or lesser molecular weight but is impermeable to cellular and humoral components of the body im- mune system.

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