Implantable devices and methods for treatment of pain by...

A - Human Necessities – 61 – K

Patent

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A61K 31/4468 (2006.01) A61F 2/02 (2006.01) A61K 9/00 (2006.01) A61L 27/00 (2006.01) A61L 27/54 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2457097

The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element that defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

L'invention concerne des dispositifs et des méthodes de traitement de la douleur. Le dispositif de distribution de médicament est un système conçu pour être implanté en totalité chez un sujet et soulager une douleur à l'aide de fentanyl ou d'un congénère de fentanyl (<i>par exemple</i>, sufentanil) pendant une durée prolongée (<i> par exemple</i>, 3 jours ou plus). Ledit dispositif comprend un logement définissant un réservoir qui contient une formulation de médicament, une pompe reliée de manière fonctionnelle audit logement afin de faciliter la sortie du médicament hors du réservoir et du dispositif, et un élément à dilatation thermique définissant un chemin d'écoulement qui comprend un canal à dilatation thermique destiné à recevoir une formulation thermiquement dilatée pour le réservoir. Ledit dispositif peut également comprendre un clapet positionné dans le chemin d'écoulement de façon à empêcher la sortie du médicament du réservoir avant son utilisation.

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