Implantable elastomeric depot compositions, uses thereof and...

Details Implantable elastomeric depot compositions, uses thereof and... Implantable elastomeric depot compositions, uses thereof and...

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2527664

Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

L'invention porte sur des procédés et des compositions d'administration systémique ou locale d'un agent bénéfique à un sujet, et comprend, par exemple, des compositions en dépôt élastomère implantables qui peuvent être injectées dans un endroit désiré et fournissent une libération contrôlée d'un agent bénéfique pendant une longue durée. Ces compositions contiennent un polymère élastomère biocomptabile, un solvant biocompatible possédant une faible miscibilité à l'eau qui forme un gel visqueux élastomère avec le polymère et limite l'absorption d'eau par l'implant, et un agent bénéfique.

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