Implantable medical devices comprising a flavonoid or...

A - Human Necessities – 61 – L

Patent

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A61L 31/16 (2006.01)

Patent

CA 2617728

The present invention relates to implantable medical devices, such as stents, that comprise a composition for controlled delivery of flavonoids or a derivative thereof. The flavonoids are aimed at preventing or reducing secondary complications which can occur following implantation of the device such as e.g. occlusive and catastrophic vascular phenomena. The invention further relates to the inclusion of additional therapeutic agents in the system that may have antiproliferative, antimitotic, antimicrobial, anticoagulant, fibrinolytic, anti-inflammatory, immunosurpressive, and anti-angiogenic activities. The composition comprising the flavonoids and optional further therapeutic agents may be used in methods for treating or preventing narrowing or obstruction of a body passageway. In particular the devices and compositions of the invention are useful in methods for treating or preventing restenosis, e.g. subsequent to angioplasty and/or for preventing or reducing acute, subacute and chronic secondary complications associated with angioplasty, such as e.g. thrombus.

L'invention concerne des dispositifs médicaux implantables, par exemple des endoprothèses, qui comprennent une composition destinée à l'administration régulée de flavonoïdes ou un dérivé de ceux-ci. Les flavonoïdes permettent de prévenir ou de réduire les complications secondaires susceptibles de survenir à la suite de l'implantation du dispositif, par exemple des phénomènes vasculaires catastrophiques occlusifs. L'invention concerne en outre l'inclusion d'agents thérapeutiques additionnels dans le système susceptibles d'avoir des activités antiprolifératives, antimitotiques, antimicrobiennes, anticoagulantes, fibrinolytiques, anti-inflammatoires, immunosuppressives, et anti-angiogéniques. La composition comprenant les flavonoïdes et d'autres agents thérapeutiques optionnels peut servir dans des procédés de traitement ou de prévention du rétrécissement ou de l'obstruction d'un passage corporel. Plus précisément, les dispositifs et les compositions selon l'invention sont utilisés dans des procédés de traitement ou de prévention de la resténose, par exemple à la suite d'une angioplastie, et/ou de prévention ou de réduction de complications secondaires aiguës, subaiguës et chroniques associées à l'angioplastie, par exemple le thrombus.

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