Implantable or insertable medical device resistant to...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/36 (2006.01) A61L 2/232 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2478787

Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

Cette invention concerne des dispositifs médicaux implantables ou insérables qui résistent à la croissance microbienne sur eux-mêmes ou à proximité d'eux-mêmes, ainsi qu'à l'adhésion microbienne et à la formation de biofilms. L'invention concerne en particulier des dispositifs médicaux implantables ou insérables comprenant au moins une région polymère à matrice biocompatible, un agent anti-mcrobien résistant à la croissance microbienne et un inhibiteur de synthèse/adhésion microbienne qui empêche les microbes de se fixer et prévient la synthèse et l'accumulation de biofilms sur la surface desdits dispositifs médicaux. Sont également décrits des procédés de fabrication de tels dispositifs dans des conditions qui empêchent sensiblement la séparation de l'un quelconque desdits agents bioactifs sur une surface du polymère à matrice biocompatible ainsi qu'une modification chimique de ces agents.

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