A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 31/16 (2006.01) A61L 31/04 (2006.01)
Patent
CA 2557544
Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents
L'invention concerne des dispositifs médicaux à implanter ou insérer résistants à la prolifération microbienne sur le dispositif et dans son environnement et résistants à l'adhérence microbienne et à la formation d'un biofilm sur le dispositif. L'invention concerne notamment des dispositifs médicaux à implanter ou insérer comprenant au moins une zone polymère matrice biocompatible, un agent antimicrobien fournissant la résistance à la prolifération microbienne et/ou un inhibiteur de l'adhérence microbienne/synthèse d'un biofilm permettant d'empêcher la fixation des microbes et la synthèse et l'accumulation d'un biofilm sur la surface du dispositif médical. L'invention concerne des procédés de production de tels dispositifs dans des conditions qui empêchent sensiblement, de préférence, la division de tout agent bioactif à la surface du polymère matrice biocompatible et empêchent sensiblement la modification chimique de ces agents bioactifs.
Bucay-Couto Weenna
Li Jianmin
Miller Kathleen M.
Boston Scientific Limited
Boston Scientific Scimed Inc.
Smart & Biggar
LandOfFree
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