Implantable or insertable medical devices for controlled...

Details Implantable or insertable medical devices for controlled... Implantable or insertable medical devices for controlled...

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61F 2/06 (2006.01) A61K 9/00 (2006.01) A61L 29/16 (2006.01) A61L 29/18 (2006.01) A61L 31/18 (2006.01) A61M 31/00 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2506963

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.

L'invention concerne des dispositifs médicaux implantables ou insérables comprenant (a) un polymère biocompatible ; et (b) au moins un agent thérapeutique choisi parmi des anti-inflammatoires, analgésiques, anesthésiques et antispasmodiques. Lesdits dispositifs médicaux sont conçus pour être implantés ou insérés dans un site associé à la douleur ou au malaise lors de l'implantation ou de l'insertion. Dans nombre de modes de réalisation, l'agent thérapeutique sera choisi parmi au moins un (i) de kétorolac et des sels pharmaceutiquement acceptables de ce dernier (par exemple kétorolac trométhamine) et (ii) 4-diéthylamino-2-butynyle phényle cyclohexyl glycolate et des sels pharmaceutiquement acceptables de ce dernier (par exemple chlorure d'oxybutynine). L'invention concerne également des utilisations de ces dispositifs médicaux implantables et insérables qui visent notamment à diminuer les douleurs et malaises associés à leur implantation ou insertion. D'autres utilisations consistent également à réduire l'accumulation microbienne le long du dispositif. L'invention concerne enfin des procédés de fabrication de dispositifs médicaux implantables ou insérables.

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