Implantable polymeric device for sustained release of...

Details Implantable polymeric device for sustained release of... Implantable polymeric device for sustained release of...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/381 (2006.01) A61K 31/4045 (2006.01) A61K 31/428 (2006.01) A61K 31/473 (2006.01) A61K 31/48 (2006.01) A61K 31/485 (2006.01) A61K 31/4985 (2006.01) A61K 47/32 (2006.01) A61P 25/16 (2006.01)

Patent

CA 2520613

The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist

La présente invention concerne des compositions, des procédés et des kits pour traiter la maladie de Parkinson et d'autres états pathologiques, pour lesquels le traitement avec un agoniste de la dopamine présente des avantages thérapeutiques. L'invention a pour objet un dispositif polymère non-érosif bio-compatible qui libère en continu l'agoniste de la dopamine avec une cinétique de libération généralement linéaire pendant des durées importantes. L'agoniste de la dopamine est libéré à travers des pores qui s'ouvrent sur la surface de la matrice polymère dans laquelle il est encapsulé. Le dispositif peut être administré par voie sous-cutanée à un individu qui a besoin d'un traitement continu par l'agoniste de la dopamine.

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