A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/26 (2006.01) A61K 9/32 (2006.01) A61K 31/485 (2006.01) A61P 25/32 (2006.01) A61P 25/34 (2006.01)
Patent
CA 2526101
The present invention provides compositions, methods, and kits for administration of nalmefene for treatment of alcoholism, nicotine dependence, or another condition for which treatment with nalmefene is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases nalmefene continuously with generally linear release kinetics for extended periods of time. Nalmefene is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with nalmefene.
La présente invention concerne des compositions, des procédés et des kits d'administration de nalmefène pour le traitement de l'alcoolisme, de la dépendance à la nicotine et d'autres états dans lesquels un traitement au nalmefène est thérapeutiquement bénéfique. L'invention concerne un dispositif polymère biocompatible non érodable lequel libère du nalmefène de façon continue avec une cinétique de libération générale linéaire sur des durées prolongées. Le nalmefène est libéré à travers des pores qui s'ouvrent sur la surface de la matrice polymère dans laquelle il est encapsulé. Le dispositif peut être administré par voie sous-cutanée à un individu nécessitant un traitement continu au nalmefène.
Bucalo Louis R.
Costantini Lauren
Patel Rajesh A.
Borden Ladner Gervais Llp
Titan Pharmaceuticals Inc.
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