Implantation of prosthetic devices

Details Implantation of prosthetic devices Implantation of prosthetic devices

A - Human Necessities

61

F

117/130, 3/141,

A61F 2/00 (2006.01) A61F 2/14 (2006.01) A61K 6/00 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01)

Patent

CA 1328151

IMPLANTATION OF PROSTHETIC DEVICES ABSTRACT OF THE DISCLOSURE Prosthetic devices are prepared for subepithelial implantation by coating their surfaces with a coating comprising crosslinked or uncrosslinked fibronectin. If the surface of the device comprises a material which does not normally bind fibronectin, it is pretreated, for example, by coating with poly(L-lysine). The coated prosthetic device is implanted by removing a portion of the epithelium, affixing the coated device to the subepithelial tissue optionally replacing all or part of the removed epithelium, and allowing new epithelial tissue to grow over and affix itself to the surface of the prosthetic device. The method of the invention can be used to implant contact lenses permanently beneath the epithelium of the cornea.

582604

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