Implanted device containing tumor cells for the treatment of...

A - Human Necessities – 61 – M

Patent

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A61M 37/00 (2006.01) A61K 9/00 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2194555

An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor, the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.

L'invention a pour objet un dispositif implantable destiné à la prévention ou au traitement du cancer. Ledit dispositif est constitué d'une chambre implantable contenant des cellules tumorales ou bien des cellules somatiques conçues par génie génétique pour l'expression d'au moins un antigène correspondant à l'antigène présent dans la tumeur du malade. La chambre comprend une paroi poreuse permettant, lors de son utilisation, d'établir une limite entre les cellules immunitaires présentées par le malade et les cellules contenues dans ladite chambre, la limite étant suffisamment poreuse pour permettre le passage d'une matière antigénique sous-cellulaire, tout en empêchant le passage des cellules contenues dans la chambre et des cellules immunitaires présentées par le malade à travers ladite limite.

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