Implanting devices for release of neuroinhibitory compounds

Details Implanting devices for release of neuroinhibitory compounds Implanting devices for release of neuroinhibitory compounds

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 9/00 (2006.01) A61K 9/66 (2006.01) A61K 31/195 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2139324

Methods are disclosed for the alleviation of movement disorders via the implantation of static devices which focally release neuroinhibitory compounds to preselected brain areas. Pathological conditions to be treated by these methods include parkinsonian movement disorders, Huntington's chorea, and epileptiform seizure activity. In the treatment of parkinsonism, target areas implantation include the subthalamic nucleus, the globus pallidus internus, and the substantia nigra pars reticulata. In the treatment of epilepsy, implants may be placed in an epileptogenic focus area of neural over-activity. The devices may be polymeric implants that release neuroinhibitory compounds such as GABA, GABA agonists, GABA potentiators, action potential blockers and voltage dependent calcium channel blockers, and glutamate antagonists. Alternatively, the devices may contain living cells which secrete neuroinhibitory compounds.

Méthodes permettant d'alléger les symptômes de troubles du mouvement. La méthode consiste à implanter des dispositifs statiques qui libèrent, de manière ciblée, des composés neuroinhibiteurs à des endroits préétablis du cerveau. Les cas pathologiques à traiter par ces méthodes comprennent des troubles du mouvement dus à la maladie de Parkinson, à la chorée de Huntington et aux crises épileptiformes. Pour traiter le parkinsonisme, les dispositifs sont placés à des endroits ciblés comme le corps de Luys, le globus pallidus internus et la pars reticulata de la substantia nigra. Pour traiter l'épilepsie, les dispositifs sont placés dans une zone épileptogène cible de suractivité neuronale. Les dispositifs peuvent être constitués d'implants polymériques qui libèrent des composés neuroinhibiteurs, tels que le GABA, des agonistes du GABA, des potentialisateurs du GABA, des inhibiteurs de potentiel d'action, des inhibiteurs calciques dépendant de la tension et des antagonistes du glutamate. Les dispositifs peuvent aussi contenir des cellules vivantes qui sécrètent des composés neuroinhibiteurs.

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