A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2346769
This invention provides methods and compositions for treating tumors by implanting near the tumor and alloactivated cell population. The cell population is made up of a plurality of third-party donor cells that have been cultured together ex vivo, and harvested near the time of peak cytokine secretion. Once placed in the tumor bed, the alloactivated cells recruit active participation of the host, which then reacts against the tumor and provides a level of ongoing protection. Employing multiple third party donor cells confers particular advantages in terms of effectiveness, timing, and ease of use.
L'invention concerne des procédés et des compositions qui permettent de traiter une tumeur par implantation d'une population cellulaire alloactivée à proximité de la tumeur. La population cellulaire est constituée d'une pluralité de cellules donneuses tierces cultivées ensemble ex vivo et récoltées presque au moment de la sécrétion maximale de cytokine. Une fois placées dans le lit de la tumeur, les cellules alloactivées sollicitent une participation active de l'hôte qui réagit alors contre la tumeur et fournit un niveau de protection continue. L'utilisation de multiples cellules donneuses tierces confère des avantages particuliers en termes d'efficacité, de délai et de facilité d'emploi.
Granger Gale A.
Thompson James A.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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