A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/28 (2006.01) A61L 27/54 (2006.01)
Patent
CA 2539151
The present invention is directed to implants that include therapeutic molecules bonded to their surfaces. The therapeutic molecules interact with cells that are adjacent, near, or adhering to the implant. The covalently- bonded therapeutic molecules may be released from the implant surface by changes in pH or enzymes characteristic of cells adjacent to the implant. Preferably the covalently-bonded agents include an antibiotics that are released from the implant surface by bacteria and in this way ensures that the antibiotic is released at sites on the implant that would serve as centers for both bacterial colonization and biofilm formation.
L'invention concerne des implants comprenant des molécules thérapeutiques liées à leurs surfaces. Les molécules thérapeutiques inter-réagissent avec des cellules qui sont adjacentes, au voisinage, ou adhérentes à l'implant. Les molécules thérapeutiques liées par covalence peuvent être libérées de la surface de l'implant par changement du pH ou des caractéristiques enzymatiques des cellules adjacentes à l'implant. De préférence, les agents liés par covalence comprennent des antibiotiques qui sont libérés de la surface de l'implant par des bactéries, et assurent de cette façon que l'antibiotique est libéré à des sites sur l'implant, aptes à servir de centres, à la fois pour une colonisation bactérienne et une formation de biofilm.
Hickok Noreen J.
Parvizi Javad
Wickstrom Eric
Gowling Lafleur Henderson Llp
Hickok Noreen J.
Parvizi Javad
Smart Tech Lp
Wickstrom Eric
LandOfFree
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