Improved 7-chloroquinaldine synthesis

Details Improved 7-chloroquinaldine synthesis Improved 7-chloroquinaldine synthesis

C - Chemistry, Metallurgy

07

D

C07D 215/18 (2006.01)

Patent

CA 2080406

An improved process is described which utilizes tetrachloro-1,4(or 1,2)-quinone as an oxidant in the Doebner-Miller synthesis of 7-chloroquinaldine, a starting material in the preparation of leukotriene antagonists. The process improves yield and eliminates the need of forming a ZnC1 2 complex to isolate the end product.

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