Improved activation of recombinant proteins

Details Improved activation of recombinant proteins Improved activation of recombinant proteins

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 14/535 (2006.01) C12N 15/27 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2061569

A process for the activation of recombinant proteins which are present in at least a partially inactive form in which a protein is activated by known solubilization or/and renaturation techniques, said protein having additional helper sequences 2 to 50 amino acids in length at its N- or/and C-terminus whereby the relative hydrophobicity of these helper sequences which is calculated as the sum of the relative hydrophobicity specified in Table 1 for the individual amino acids has a negative numerical value.

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