Improved adenoviral vectors and uses thereof

Details Improved adenoviral vectors and uses thereof Improved adenoviral vectors and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2583843

The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre-existing immunity in a minority of the human population and which harbour a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus and Adenovirus Receptor (CAR) and a hexon protein from an adenovirus serotype that encounters pre-existing immunity in a low percentage of the human population.

L'invention concerne des vecteurs adénoviraux recombinés à base de vecteurs adénoviraux présentant une immunité pré-existante dans une minorité de la population humaine et comprenant une capside chimère. Cette capside chimère comprend des protéines fibres dont au moins le domaine de la spicule d'un adénovirus humain se lie au récepteur du virus Coxsackievirus et des adénovirus, et une protéine d'hexon d'un sérotype adénoviral présentant une immunité pré-existante en faible pourcentage dans la population humaine.

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