Improved amino acid and metabolite biosynthesis

Details Improved amino acid and metabolite biosynthesis Improved amino acid and metabolite biosynthesis

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) C12N 15/74 (2006.01) C12P 13/04 (2006.01) C12P 13/08 (2006.01) C12P 13/12 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2611513

Bacterial strains that are engineered to increase the production of amino acids, including aspartate-derived amino acids (e.g., methionine, lysine, threonine, isoleucine, and S-adenosylmethionine (S-AM)) and cysteine, and related metabolites are described. The strains can be genetically engineered to harbor one or more nucleic acid molecules (e.g., recombinant nucleic acid molecules) encoding a polypeptide (e.g., a polypeptide that is heterologous or homologous to the host cell) and/or they may be engineered to increase or decrease expression and/or activity of polypeptides (e.g., by mutation of endogenous nucleic acid sequences).

L'invention concerne des souches bactériennes modifiées en vue d'une augmentation de la production d'acides aminés, tels que les acides aminés dérivés de l'aspartate (par ex., la méthionine, la lysine, la thréonine, l'isoleucine et la S-adénosylméthionine (S-AM)) et la cystéine, ainsi que des métabolites associés. Ces souches peuvent être génétiquement modifiées de façon à renfermer une ou plusieurs molécules d'acide nucléique (par ex., des molécules d'acide nucléique recombinées) codant pour un polypeptide (par ex., un polypeptide hétérologue ou homologue vis-à-vis de la cellule hôte) et/ou peuvent être modifiées en vue d'une augmentation ou d'une réduction de l'expression et/ou de l'activité de polypeptides (par ex., par mutation des séquences d'acide nucléique endogènes).

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