Improved anti-tnfr1 polypeptides, antibody variable domains...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2750477

The invention relates to anti-TNFR1 polypeptides, antibody single variable domains (dAbs), antagonists and multispecific ligands, as well as methods and uses of these. The anti-TNFR1 polypeptides, antibody single variable domains (dAbs), antagonists and multispecific ligands are useful for treating and/or preventing inflammatory disease, such as arthritis or COPD, as well as for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient.

La présente invention concerne des polypeptides, des domaines variables uniques d'anticorps (les dAbs), des antagonistes, et des ligands multispécifiques, tous anti-TNFR1, ainsi que des méthodes et des utilisations les mettant en uvre. Les polypeptides, dAbs, antagonistes, et ligands multispécifiques, tous anti-TNFR1, sont utiles pour le traitement et/ou la prévention de maladies inflammatoires, telles que l'arthrite ou la bronchopneumopathie chronique obstructive (BPCO). Ils peuvent également être administrés par voie pulmonaire ou orale et distribués au poumon ou au tractus gastro-intestinal d'un patient.

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