Improved anti-viral and anti-tumor chemotherapy by...

Details Improved anti-viral and anti-tumor chemotherapy by... Improved anti-viral and anti-tumor chemotherapy by...

G - Physics

01

N

G01N 33/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) A01N 37/18 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2417550

The present invention provides methods using erythropoietin to improve the tolerance of anti-viral and anti-tumor chemotherapeutic regimens containing interferon. The invention also described improved methods to treat chronic HCV by adjusting the dose of ribavirin to tailor the active dose of the drug while supporting the hemoglobin levels in the patient with EPO. The present invention also provides anti-viral dosing regimens, particularly for chronic HCV comprising administration of an interferon containing anti-viral medicament, EPO, and a compound that reduces the amount of active tumor necrosis factor in the subject.

L'invention concerne des procédés faisant appel à l'érythropoïétine afin que soit améliorée la tolérance à des schémas posologiques chimiothérapeutiques antiviraux et anticancéreux contenant de l'interféron. L'invention concerne également des procédés améliorés de traitement du virus de l'hépatite C chronique, par ajustement de la dose de ribavirine pour l'adapter à la dose active du médicament tout en maintenant les niveaux d'hémoglobine chez le patient avec l'EPO. Cette invention concerne également des schémas posologiques de dosage antiviraux, plus spécifiquement pour le virus de l'hépatite C chronique, qui comprennent l'administration d'un interféron contenant un médicament antiviral, d'EPO, et d'un composé qui diminue la quantité de facteur actif de nécrose des tumeurs chez le sujet.

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