Improved antibodies having altered effector function and...

Details Improved antibodies having altered effector function and... Improved antibodies having altered effector function and...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/735 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2536408

The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.

L'invention se rapporte à un procédé de fabrication de polypeptides contenant Fc aglycosylés, tels des anticorps, présentant une fonction d'effecteur voulue. Cette invention porte aussi sur des anticorps aglycosylés fabriqués selon ce procédé ainsi que sur des procédés d'utilisation de ces anticorps en tant qu'agents thérapeutiques.

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