C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) C40B 40/02 (2006.01) C40B 40/08 (2006.01) C40B 50/06 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2736430
The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided.
La présente invention concerne des banques de présentation d'ARN in vitro améliorées pour permettre l'expression et la sélection fiables de molécules d'anticorps scFv à partir de banques d'expression. Les banques d'anticorps scFv de l'invention contiennent un lieur inter-domaines optimisé, raccourci qui améliore l'expression d'anticorps scFv. Les banques d'anticorps scFv comprennent en outre des codes à barres d'acides nucléiques courts qui permettent l'identification de clones individuels de banque, de banques ou de sous-ensembles de celles-ci. La présente invention concerne en outre des amorces pour générer, amplifier et typer spectralement les banques d'anticorps scFv de l'invention.
Hsieh Chung-Ming
Kutskova Yuliya A.
Memmott John E.
Abbott Laboratories
Torys Llp
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