Improved apo e analogs and methods for their use

A - Human Necessities – 61 – K

Patent

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A61K 38/00 (2006.01)

Patent

CA 2578146

Novel ApoE peptide derivatives and ApoE-protein transduction domain conjugates are disclosed which are useful for treating disorders including CNS inflammation, traumatic brain injury, inflammatory bowel disease (also known as Crohn's Disease or ulcerative colitis), cerebral ischemia, atherosclerosis, sepsis, multiple sclerosis and arthritic diseases, Alzheimer's Disease and other brain disorders. The invention encompasses methods for protecting subjects having undergone irradiation or radiotherapy by administration of ApoE or at least one ApoE mimetic peptide.

L'invention concerne de nouveaux dérivés peptidiques d'ApoE et des conjugués de domaine de transduction de protéine d'ApoE. Ces dérivés et ces conjugués sont utiles pour traiter des troubles comprenant une inflammation du système nerveux central, une lésion cérébrale traumatique, une maladie intestinale inflammatoire (également connue sous le nom de maladie de Crohn ou de colite ulcéreuse), une ischémie cérébrale, une athérosclérose, une sepsis, une sclérose en plaques et des maladies arthritiques, la maladie d'Alzheimer et d'autres troubles cérébraux. L'invention concerne des méthodes de protection de patient ayant subi une irradiation ou une radiothérapie, par l'administration d'ApoE ou d'au moins un peptide mimétique d'ApoE.

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