Improved artificial blood fluids

A - Human Necessities – 01 – N

Patent

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A01N 1/02 (2006.01) A01N 43/04 (2006.01) A01N 65/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/42 (2006.01)

Patent

CA 2345895

The present invention provides improved artificial blood fluids. In accordance with preferred embodiments, artificial blood fluids with synthetic or natural oxygen carrying compounds are improved through the inclusion of small amounts of blood soluble microflow drag reducing factors. Physiologically acceptable carriers are preferred as those having a polyethylene glycol adjuvant. The concentration of microflow drag reducing factor is from about 0.1 ppm to about 10,000 ppm by weight of the blood fluid. Certain embodiments feature the employment of certain third and fourth generation dendritic polymers to improve emulsification of artificial blood fluids.

La présente invention concerne des fluides sanguins artificiels améliorés. Selon les modes de réalisation préférés de l'invention, il est possible d'améliorer les propriétés de fluides sanguins artificiels véhiculant des composés porteurs d'oxygène naturels ou de synthèse par inclusion de petites doses de facteurs de réduction de la traînée de micro-écoulement solubles dans le sang. On préfère les transporteurs physiologiquement acceptables aux vecteurs associés à un adjuvant de polyéthylène glycol. La concentration du facteur de réduction de la traînée de micro-écoulement est comprise entre 0,1 ppm environ et 10.000 ppm environ par rapport au poids du fluide sanguin. Selon certains modes de réalisation, l'invention utilise des dendrimères de troisième ou de quatrième génération pour améliorer l'émulsification des fluides sanguins artificiels.

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