Improved arylamine synthesis

Details Improved arylamine synthesis Improved arylamine synthesis

C - Chemistry, Metallurgy

07

C

C07C 249/02 (2006.01) C07C 209/10 (2006.01) C07C 209/18 (2006.01) C07C 227/06 (2006.01) C07C 251/04 (2006.01) C07C 211/45 (2006.01) C07C 229/52 (2006.01) C07C 251/24 (2006.01)

Patent

CA 2336976

The present invention provides a process for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined, in the presence of a transition metal catalyst, under conditions wherein the transition metal catalyst catalyzes the formation of a carbon- nitrogen bond between the activated carbon of the arene and the imine nitrogen; and 2) the resulting N-aryl imine is transformed, via any of a number of standard protocols, to the primary arylamine. The process of the invention may also be exploited in the preparation of vinylamines.

L'invention concerne un procédé de préparation d'une large gamme d'arylamines primaires. On prépare ces arylamines sont préparées au moyen de deux transformations efficaces et simples: 1) on combine un groupe aryle activé et une groupe imine en présente d'un catalyseur de métal de transition dans des conditions dans lesquelles ce dernier catalyse la formation d'une liaison carbone-azote entre le carbone activé de l'arène et azote iminé; et 2) on transforme la N-aryl-imine résultante en arylamine primaire au moyen d'un quelconque protocole courant. On peut également utiliser ce procédé pour préparer des vinylamines.

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