Improved bioadhesive pharmaceutical delivery system

A - Human Necessities – 61 – K

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Details

A61K 9/68 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2194168

A solid or semi-solid bioadherent, orally ingestible drug delivery system containing a water-in-coil system having at least two phases, one phase comprises from about 25 % to about 75 % by volume of an internal hydrophilic phase and the other phase comprises from about 25 % to to about 75 % by volume of an external hydrophobic phase wherein the external hydrophobic phase is comprised of three components: a) an emulsifier, b) a glyceride ester and c) a wax material.

La présente invention concerne un système d'administration de médicaments bioadhérents solides ou semi-solides, oralement ingérables. Il se compose d'un système eau-dans-l'huile présentant au moins deux phases. Une phase comporte un volume de 25 % à 75 % de phase hydrophile interne, et l'autre phase comporte un volume de 25 % à 75 % de phase hydrophobe externe. La phase hydrophobe externe est constituée de trois composants: a) un émulsifiant, b) un ester de glycéride et c) une substance cireuse.

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