Improved cancer treatment with temozolomide

Details Improved cancer treatment with temozolomide Improved cancer treatment with temozolomide

A - Human Necessities

61

K

A61K 31/4188 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2368614

A method for treating a patient afflicted with cancer is provided, in which temozolomide is administered to the patient for at least two cycles of a cyclical dosing schedule, wherein each cycle has a dosing period of 5 to 25 days, in which temo-zolomide is administered daily, at a dose of 40 to 150 mg/m2/day, followed by a rest period of 5 to 14 days in which temozolomide is not administered. Also provided is a medical kit for administering temozolomide, having printed instructions for administering temozolomide according to the cyclical dosing schedule set forth above, and a supply of temozolomide in dosage units for at least one cycle, wherein each dosage unit contains 5 to 250 mg of temozolomide and a pharmaceutically acceptable carrier.

L'invention concerne un procédé de traitement d'un patient atteint du cancer auquel on administre le témozolomide pendant au moins deux cycles d'un programme de posologie cyclique. Chaque cycle correspond à une période de posologie de 5 à 25 jours pendant laquelle le témozolomide est administré quotidiennement par dose de 40 à 150 mg/m<2>/jour, suivie d'une période de repos de 5 à 14 jours pendant laquelle le témozolomide n'est pas administré. L'invention porte également sur une trousse destinée à l'administration du témozolomide avec, imprimées, des instructions pour l'administration du témozolomide selon le programme de posologie cyclique susmentionné, et une réserve de témozolomide en doses pour au moins un cycle, chaque dose contenant 5 à 250 mg de témozolomide et un porteur pharmaceutiquement acceptable.

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