Improved cell lines and their use in encapsulated cell...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/00 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2750027

The present invention relates to generation of cell lines expressing recombinant proteins for use in naked and encapsulated cell biodelivery of secreted therapeutic molecules. In one embodiment the cell line is human. In another aspect of the invention the transposon system is used for generating a cell line for secretion of a biologically active polypeptide.

La présente invention concerne la génération de lignées cellulaires exprimant des protéines recombinantes pour une utilisation dans la biodélivrance de cellules nues et encapsulées de molécules thérapeutiques sécrétées. Selon un mode de réalisation, la lignée cellulaire est humaine. Selon un autre aspect de l'invention, le système de transposon est utilisé pour générer une lignée cellulaire pour la sécrétion d'un polypeptide biologiquement actif.

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