C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2761274
The invention concerns the field of cell culture technology. It concerns production host cell lines with increased expression of ribosomal RNA (rRNA) achieved through reducing expression of NoCR proteins, especially of TIP-5. Those cell lines have improved secretion and growth characteristics in comparison to control cell lines. The invention further concerns a method of producing proteins using the cells generated by the described method.
La présente invention concerne le domaine de la technologie de la culture cellulaire, elle concerne également la production de lignées de cellules hôtes ayant une expression accrue d'ARN ribosomique (ARNr) obtenue par une réduction de l'expression de protéines NoCR, plus particulièrement de TIP-5. Ces lignées cellulaires présentent des caractéristiques de sécrétion et de croissance améliorées comparativement aux lignées cellulaires témoins. Cette invention porte également sur un procédé de production de protéines au moyen des cellules produites à l'aide dudit procédé.
Enenkel Barbara
Florin Lore
Fussenegger Martin
Kaufmann Hitto
Santoro Raffaella
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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