Improved crystalline form of the compound a-348441

Details Improved crystalline form of the compound a-348441 Improved crystalline form of the compound a-348441

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/575 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2614048

There is provided a hemihydrate of (3.beta., 5.beta., 7.alpha., 12.alpha.) -7 , 12- dihydroxy-3-{2- [ {4- [17.beta.-hydroxy-3-oxo-17.alpha.-prop-l-ynylestra- 4 , 9-dien-ll.beta.-yl] phenyl } (methyl) amino] ethoxy} cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2.theta. = 6.58~0.2, 8.54+0.2, 12.28~0.2, and 19.68~0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.

Cette invention concerne un semi-hydrate d'acide (3.beta., 5.beta., 7.alpha., 12.alpha.)-7,12-dihydroxy-3-{2-[{4-[17.beta.-hydroxy-3-oxo-17.alpha.-prop-1-ynylestra-4,9-dien-11.beta.-yl] phényl} (méthyl) amino] éthoxy} cholan-24-ique sous forme cristalline qui se caractérise par un diagramme de diffraction des rayons X dont les crêtes principales à 2.theta. sont égales à 6,58±0,2, 8,54+0,2, 12,28±0,2 et 19,68±0,2. Ce matériau cristallin est utilisé dans le traitement d'états associés à un excès de réponse glucocorticoïde hépatique.

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