C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2547877
The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
La présente invention concerne de nouveaux procédés permettant de concevoir des protéines, en particulier des cytokines. Ces procédés permettent de stabiliser ces cytokines et de modifier leur sélectivité/spécificité par rapport à leurs récepteurs apparentés. L'invention se rapporte également à diverses protéines modifiées conçues à l'aide des procédés selon l'invention.
Cool Robbert H.
Fernandez-Ballester Gregorio
Mullally Margaret M.
Quax Wilhelmus J.
Samali Afshin
European Molecular Biology Laboratory
Kirby Eades Gale Baker
National University Of Ireland
University Of Groningen
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