Improved delivery of tetrahydrocannabinol

Details Improved delivery of tetrahydrocannabinol Improved delivery of tetrahydrocannabinol

A - Human Necessities

61

K

A61K 31/353 (2006.01) A61K 9/107 (2006.01) A61K 47/14 (2006.01) A61K 47/34 (2006.01) A61P 1/08 (2006.01)

Patent

CA 2618705

A self-emulsifying drug delivery system to improve dissolution, stability, and bioavailability of drug compounds of dronabinol or other cannabinoids. The drug compound(s) are dissolved in an oily medium (e.g. triglycerides and/or mixed glycerides and/or free fatty acids containing medium and/or long chain saturated, mono-unsaturated, and/or poly-unsaturated free fatty acids) together with at least one surfactant. The surfactant promotes self- emulsification, thereby promoting targeted chylomicron delivery and optimal bioavailability to a mammalian intestinal lumen. A dosage form can optionally include co-solvents, anti-oxidants, viscosity modifying agents, cytochrome P450 metabolic inhibitors, P-GP efflux inhibitors, and amphiphilic/non- amphiphilic solutes to induce semi-solid formation for targeted release rates.

L'invention concerne un système d'administration de médicament auto-émulsifiant permettant d'améliorer la dissolution, la stabilité et la biodisponibilité de composés médicamenteux de dronabinol ou d'autres cannabinoïdes. Les composés médicamenteux sont dissous dans un milieu huileux (par exemple, des triglycérides et/ou des gylcérides mélangés et/ou des acides gras libres renfermant des acides gras libres saturés, mono-insaturés et/ou poly-insaturés à chaîne moyenne et/ou longue) conjointement avec un tensioactif. Celui-ci favorise l'auto-émulsification, favorisant ainsi l'administration ciblée de chylomicron et une biodisponibilité optimale dans une lumière intestinale d'un mammifère. Une forme galénique peut éventuellement comprendre des co-solvants, des antioxydants, des agents de modification de la viscosité, des inhibiteurs métaboliques du cytochrome P450, des inhibiteurs de l'efflux de la P-GP et des solutés amphiphiles/non-amphiphiles, aux fins d'induction d'une formation semi-solide destinée à des vitesses de libération ciblées.

Affiliated with

Also associated with

Rating

Improved delivery of tetrahydrocannabinol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Improved delivery of tetrahydrocannabinol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved delivery of tetrahydrocannabinol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1600093