Improved dosing and scheduling of oligomers

Details Improved dosing and scheduling of oligomers Improved dosing and scheduling of oligomers

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61N 5/00 (2006.01) A61N 7/00 (2006.01)

Patent

CA 2644584

The present invention relates to a method for treating a human patient having a proliferative disorder by administering an effective amount of a pre-treatment to the patient prior to administering an effective amount of a nucleotide-based composition that inhibits the over-expression of a target gene that causes the proliferative disorder. The present invention includes pre-treatment with one or more radiotherapy such as an X ray, a proton beam, an electron beam; hyperthermic therapy, ultrasonic therapy, chemotherapy and a biologic therapy. The invention also relates to an improved dose and scheduling sequence for treating a human patient in need thereof with such a nucleotide-based inhibitor of gene expression.

La présente invention concerne une méthode destinée à traiter un patient humain atteint d'une maladie proliférative par administration à ce patient d'une dose efficace d'un prétraitement avant l'administration d'une dose efficace d'une composition nucléotidique inhibant la surexpression d'un gène cible causant cette maladie proliférative. La présente invention fait intervenir un prétraitement avec un ou plusieurs types de radiothérapie, tels qu'un traitement par rayons X, par faisceau de protons ou par faisceau d'électrons, un traitement hyperthermique, une ultrasonothérapie, une chimiothérapie et une biothérapie. L'invention concerne également une séquence d'établissement de posologie et de calendrier améliorée pour le traitement d'un patient humain le nécessitant avec un inhibiteur nucléotidique de l'expression génétique.

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