Improved enteric formulation of fluoxetin

Details Improved enteric formulation of fluoxetin Improved enteric formulation of fluoxetin

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2457385

An industrially advantageous enteric formulation of Fluoxetin without the use of hydroxypropylmethylcellulose acetate succinate and sucrose is covered by this invention. The present invention also covers said enteric formulations of Fluoxetin in the form of tablets or capsules with an optional separating layer. When in the form of capsules, the separating layer is capsule shell itself thus reducing processing step of said enteric formulations. The formulation of the present invention along with Fluoxetin or its pharmaceutically accepted salts, solvates, enantiomers or mixtures thereof including racemic mixture is also contemplated to be within the scope of present invention.

L'invention concerne une préparation entérique de fluoxétine avantageuse sur le plan industriel n'impliquant pas l'utilisation de saccharose et de succinate d'acétate d'hydroxypropylméthylcellulose. Cette invention a également trait à des préparations entériques de fluoxétine sous forme de comprimés ou de gélules pourvues d'une couche de séparation facultative. Lorsque ces préparations se présentent sous forme de gélules, la couche de séparation est la coque de la gélule même, ce qui permet de réduire l'étape de traitement desdites préparations entériques. La préparation de cette invention, ainsi que la fluoxétine ou ses sels acceptables pharmaceutiquement, les solvates, les enantiomères ou les mélanges correspondants contenant un mélange racémique sont également considérés comme étant dans la portée de cette invention.

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