Improved expression systems with sec-system secretion

Details Improved expression systems with sec-system secretion Improved expression systems with sec-system secretion

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07H 7/00 (2006.01) C07H 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/72 (2006.01) C12N 15/78 (2006.01)

Patent

CA 2546157

Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides.

L'invention concerne des procédés et des systèmes d'expression procaryotiques améliorés permettant de produire des protéines recombinantes au moyen de peptides de signal de sécrétion du système Sec au moyen des systèmes de sécrétion Sec <i>Pseudomonas fluorescens </i>. L'invention concerne également des peptides de signal de sécrétion du système sec spécifiques, ainsi que des protéines hybrides et des séquences de codage destinées à la sécrétion améliorée de protéines recombinantes et de peptides.

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